Britons travelling to Canada are being warned to be careful as police launch a huge manhunt for two men suspected of stabbing at least 10 people to death.

The men, Damien Sanderson and Myles Sanderson, are considered armed and dangerous.

In an update to its travel advice, issued in the early hours of this morning, the Foreign Office said: “If you’re in the area you should take care and follow the advice of the local authorities.”

The men are believed to gone on a rampage in an indigenous community in Saskatchewan, leaving at least 10 dead and injuring at least 15 others.

The incident in James Smith Cree Nation and nearby Weldon is one of the deadliest acts of mass violence Canada has ever seen.

Police are urging residents to be extremely vigilant as they conduct a search operation across a large and remote region.

A number of checkpoints have been set up and drivers have been urged not to pick up hitchhikers.

A dangerous persons’ alert has been sent to all mobile phones across the provinces of Saskatchewan, Manitoba and Alberta.

“Do not leave a secure location. Use caution allowing others into your residence,” Saskatchewan Royal Canadian Mounted Police (RCMP) warned people across the search area.

A state of emergency has been declared in the James Smith Cree Nation, which has a population of around 3,400, and Weldon, where just 200 people live.  

The two men were seen traveling in a black Nissan Rogue and spotted in the city of Regina, about 200 miles south of the attacks, police said.

“It appears that some of the victims may have been targeted, and some may be random. So to speak to a motive would be extremely difficult at this point in time,” Rhonda Blackmore, Commanding Officer of the Saskatchewan Royal Canadian Mounted Police, told a news conference.